GIMC SIMAI Young 2026

Session

MS05 - Multiscale Cardiac Electrophysiology: From Scalable Computational Solvers to Patient-Specific Simulations

3 Jun 2026, 16:15

Pisa

47. A Computational Model of Human iPSC-Derived Ventricular Myocyte for Calcium-Mediated Arrhythmia and Disease Modeling

Francesca Simone (Università degli Studi di Pavia)

03/06/2026, 16:15

MS05 - Multiscale Cardiac Electrophysiology: From Scalable Computational Solvers to Patient-Specific Simulations

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are widely used to investigate inherited and acquired cardiac disorders in a patient-specific context. However, their immature electrophysiological phenotype requires quantitatively calibrated dynamical models capable of mechanistically describing nonlinear calcium–voltage coupling across multiple temporal scales.

We...

57. Coupling cardiac electrophysiology models: from fine-scale to coarse-scale simulations

Sara Demo

03/06/2026, 16:30

MS05 - Multiscale Cardiac Electrophysiology: From Scalable Computational Solvers to Patient-Specific Simulations

The well-established homogenized bidomain (BD) model represents averaged intra- and extracellular behavior, providing a good compromise between physiological accuracy and computational feasibility. However, as the myocyte is not present in the model, the BD model cannot account for cell-to-cell variations, which can be properly analyzed by adopting the cell-based EMI model, in which the...

62. Second Order IMEX Time Stepping Methods for Efficient Multi-Electrode Array simulations

Sofia Tonali (Università di Pavia)

03/06/2026, 16:45

MS05 - Multiscale Cardiac Electrophysiology: From Scalable Computational Solvers to Patient-Specific Simulations

Multi-electrode arrays (MEAs) enable tissue-level electrophysiological studies of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) by recording extracellular field potentials (FPs). Recent in-silico models have improved MEA simulations by coupling detailed electrode descriptions with the Bidomain framework, a parabolic-elliptic system of nonlinear PDEs coupled with a...

85. Neural Network Emulators for Cardiac Electrophysiology Modeling in Derived Stem Cardiomyocytes

Sofia Botti (MOX, Politecnico di Milano)

03/06/2026, 17:00

MS05 - Multiscale Cardiac Electrophysiology: From Scalable Computational Solvers to Patient-Specific Simulations

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC--CMs) provide a physiologically relevant platform for studying cardiac electrophysiology under both healthy and pathological conditions, as well as for drug cardiotoxicity screening. Multi-electrode arrays (MEAs) enable non-invasive, long-term recording of extracellular field potentials from hiPSC-CM monolayers, capturing...

86. Multimodal Personalisation of Cardiac Electrophysiology Models Integrating 12-Lead ECG and CT Imaging

Buntheng LY (Institut Hospitalo-Universitaire Liryc, France)

03/06/2026, 17:15

MS05 - Multiscale Cardiac Electrophysiology: From Scalable Computational Solvers to Patient-Specific Simulations

Recent advances in cardiac electrophysiological modelling, coupled with modern computational technology, enable fast in silico simulation of ventricular tachycardia (VT), showing strong potential for applications in arrhythmia risk stratification and therapy planning, such as catheter ablation. However, accurate patient-specific model personalisation remains a major challenge, limiting...